Highly enantioselective Ag(i)-catalyzed [3 + 2] cycloaddition of azomethine ylides.

نویسندگان

  • James M Longmire
  • Bin Wang
  • Xumu Zhang
چکیده

A highly reactive Ag(I)-catalyzed [3 + 2] cycloaddition of azomethine ylides is founded using AgOAc as the catalytic precursor and phosphines as ligands. Using a new bis-ferrocenyl amide phosphine (FAP) as the ligand, we found that high enantioselectivities (up to 97% ee) have been achieved in the [3 + 2] cycloaddition of azomethine ylides. Up to four stereogenic centers can be established in this multicomponent coupling reaction from readily available materials such as aldehydes, aminoesters, and dipolarophiles.

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عنوان ژورنال:
  • Journal of the American Chemical Society

دوره 124 45  شماره 

صفحات  -

تاریخ انتشار 2002