Highly enantioselective Ag(i)-catalyzed [3 + 2] cycloaddition of azomethine ylides.
نویسندگان
چکیده
A highly reactive Ag(I)-catalyzed [3 + 2] cycloaddition of azomethine ylides is founded using AgOAc as the catalytic precursor and phosphines as ligands. Using a new bis-ferrocenyl amide phosphine (FAP) as the ligand, we found that high enantioselectivities (up to 97% ee) have been achieved in the [3 + 2] cycloaddition of azomethine ylides. Up to four stereogenic centers can be established in this multicomponent coupling reaction from readily available materials such as aldehydes, aminoesters, and dipolarophiles.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 124 45 شماره
صفحات -
تاریخ انتشار 2002